• Alterations in inflammatory markers after a 12-week exercise program in individuals with schizophrenia—a randomized controlled trial 

      Bigseth, Therese Torgersen; Engh, John Bjarne Abel; Andersen, Eivind; Bang-Kittilsen, Gry; Egeland, Jens; Falk, Ragnhild Sørum; Holmen, Tom Langerud; Mordal, Jon; Nielsen, Jimmi; Ueland, Thor; Vang, Torkel; Fredriksen, Mats (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      Background: In individuals with schizophrenia, inflammation is associated with depression, somatic comorbidity and reduced quality of life. Physical exercise is known to reduce inflammation in other populations, but we have only limited knowledge in the field of schizophrenia. We assessed inflammatory markers in plasma samples from individuals with schizophrenia participating in an exercise intervention ...
    • The Association Between Cardiorespiratory Fitness and Cognition Appears Neither Related to Current Physical Activity Nor Mediated by Brain-Derived Neurotrophic Factor in a Sample of Outpatients With Schizophrenia 

      Holmen, Tom Langerud; Egeland, Jens; Andersen, Eivind; Mordal, Jon; Andreassen, Ole Andreas; Ueland, Thor; Bigseth, Therese Torgersen; Bang-Kittilsen, Gry; Engh, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-25)
      <i>Objective</i>: We investigated whether levels of current physical activity (PA) contribute to the established relationship between cardiorespiratory fitness (CRF) and cognition in schizophrenia and whether brain-derived neurotrophic factor (BDNF) or its precursor proBDNF mediates this relationship. <p> <p><i>Method</i>: Sixty-one outpatients with schizophrenia spectrum disorders participated. ...
    • Effect of high-intensity interval training on cardiorespiratory fitness, physical activity and body composition in people with schizophrenia: a randomized controlled trial 

      Andersen, Eivind; Bang-Kittilsen, Gry; Bigseth, Therese Torgersen; Egeland, Jens; Holmen, Tom Langerud; Martinsen, Egil Wilhelm; Stensrud, Trine; Engh, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-27)
      <i>Background</i> - Exercise may improve cardiorespiratory fitness in people with schizophrenia, however, possible condition-specific cardiorespiratory disadvantages, a scarcity of methodologically sound studies, and conflicting results raise questions about the effect of exercise on maximal oxygen uptake (VO<sub>2max</sub>) in this group. The primary aim of this study, therefore, was to investigate ...
    • Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms 

      Bigseth, Therese Torgersen; Engh, John; Egeland, Jens; Andersen, Eivind; Andreassen, Ole; Bang-Kittilsen, Gry; Falk, Ragnhild Sørum; Holmen, Tom Langerud; Lindberg, Morten; Mordal, Jon; Nielsen, Jimmi; Steen, Nils Eiel; Ueland, Thor; Vang, Torkel; Fredriksen, Mats (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-26)
      Background - There is evidence of increased low grade inflammation (LGI) in schizophrenia patients. However, the inter-individual variation is large and the association with demographic, somatic and psychiatric factors remains unclear. Our aim was to explore whether levels of the novel LGI marker soluble urokinase plasminogen activator receptor (suPAR) were associated with clinical factors in ...